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Introduction Chronic hepatitis B virus (HBV) infection remains a serious public health issue, which is the leading cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC) ( The disorder of T cells mediated cellular immune response favored viral persistence and pathogenesis of hepatitis B ( + and CD8 + T cell responses and the production of HBV-related antibodies determine the outcome of HBV infection